组蛋白去乙酰化酶6(HDAC6),histone deacetylase 6 (HDAC6)
1)histone deacetylase 6 (HDAC6)组蛋白去乙酰化酶6(HDAC6)
2)histone acetyltransferase (HAT)/histone deacetylase (HDACs)组蛋白乙酰化酶/组蛋白去乙酰化酶
3)histone deacetylases组蛋白去乙酰化酶
1.Synthesis and activity study of a new series ofhistone deacetylases(HDACs) inhibitors of N-hydroxycinnamamide derivatives;一组新的N-羟基肉桂酰胺类组蛋白去乙酰化酶抑制剂的合成和初步活性研究
2.Histone acetyltransferases(HAT) andhistone deacetylases(HDACs) as the corresponding enzymes regulate the change of histones in two antagonist forms,acetylated or deacetylated.组蛋白乙酰转移酶(HAT)和组蛋白去乙酰化酶(HDAC)调节组蛋白乙酰化程度,HDAC在基因表达和染色体形成等方面起着重要的调节作用。
3.Histone acetyltransferases (HATs) andhistone deacetylases (HDACs) are emerging as important components of protein complexes that affect the dynamics of chromatin folding during gene transcription.组蛋白乙酰转移酶(histone acetyltransferases, HATs)和组蛋白去乙酰化酶(histone deacetylase, HDACs)可以通过调节组蛋白或转录因子的乙酰化状态来调节基因的活化或沉默。
英文短句/例句
1.Histone deacetylases inhibitors anticancer drug:Vorinostat组蛋白去乙酰化酶抑制剂类抗癌药Vorinostat
2.The Design and Synthesis of Cyclic Tetrapeptide Histone Deacetylase Inhibitors;环肽类组蛋白去乙酰化酶抑制剂的设计与合成
3.Isolation and Functional Characterization of Rice Histone Deacetylase Gene;水稻组蛋白去乙酰化酶基因的分离和功能鉴定
4.Advances in the anticancer effect of histone deacetylase inhibitor组蛋白去乙酰化酶抑制剂抗肿瘤的研究进展
5.Screening of the Proteins Interacting with the Histone Deacetylase 1 in Yeast Two-Hybird System酵母双杂交系统筛选与组蛋白去乙酰化酶1相互作用的蛋白质
6.Anticancer Activities of Histone Deacetylase and DNA Methyltransferase Inhibitors on Pancreatic Cancer;DNA甲基化酶和组蛋白去乙酰化酶抑制剂治疗胰腺癌的实验研究
7.The Establishment of Screening Models for Histone Deacetylase Inhibitors and Their Application in Screening of the Chinese Traditional Medicine Effective Components;组蛋白去乙酰化酶抑制剂筛选模型的建立及中药有效组分的筛选
8.Dynamic Changes of Histone Deacetylase 1 during Regulated Growth of Bronchial Stem Cells in Human Bronchial Regeneration;组蛋白去乙酰化酶1在气管干细胞增殖分化过程中的时空表达
9.Screening the in Vitro Anti-tumor Activities of Novel Synthetics Targeting to Histone Deacetylases靶向组蛋白去乙酰化酶新型化合物的体外抗肿瘤活性筛选
10.Molecular Mechanisms of Histone Deacetylase Inhibitors Induced Mitotic Catastrophe in Tumor Cells;组蛋白去乙酰化酶抑制剂诱导细胞有丝分裂灾变的分子机制探讨
11.Inhibition Effect of Histone Deacetylase Inhibitor FK228 on Prostate Cancer Cells;组蛋白去乙酰化酶抑制剂FK228对前列腺癌细胞的抑制作用
12.Express of HDAC6 in Primary Hepatocelluar Carcinoma and Its Clinical Significance;组蛋白去乙酰化酶6在原发性肝癌中的表达及临床意义
13.Histone Deacetylase Inhibitors of Polyoxometalates: Screening and Anti-Tumor Activity;多酸类组蛋白去乙酰化酶抑制剂的筛选及抗肿瘤活性研究
14.The Screening and Primary Functional Study of Histone Deacetylase Inhibitors from Polyoxometallates;多酸类组蛋白去乙酰化酶抑制剂的筛选及初步功能研究
15.Studies on Design、Synthesis and Activity of Hydroxamate Acids Derivatives as Histone Deacetylases Inhibitors;异羟肟酸类组蛋白去乙酰化酶抑制剂的设计合成与活性研究
16.The Effect of HDAC Inhibitor on Breast Cancer and ERα Expression;探讨组蛋白去乙酰化酶抑制剂对乳腺癌及ERα表达的影响
17.Role of Histone Deacetylase 1 in Pancreatic Cancer Cell Line: An Experimental Study;组蛋白去乙酰化酶1在胰腺癌发生机制中的作用研究
18.The Effect of Histone De-acetylase Inhibitor on RECK Gene Expression in Breast Cancer;组蛋白去乙酰化酶抑制剂对乳腺癌中RECK基因的表达影响研究
相关短句/例句
histone acetyltransferase (HAT)/histone deacetylase (HDACs)组蛋白乙酰化酶/组蛋白去乙酰化酶
3)histone deacetylases组蛋白去乙酰化酶
1.Synthesis and activity study of a new series ofhistone deacetylases(HDACs) inhibitors of N-hydroxycinnamamide derivatives;一组新的N-羟基肉桂酰胺类组蛋白去乙酰化酶抑制剂的合成和初步活性研究
2.Histone acetyltransferases(HAT) andhistone deacetylases(HDACs) as the corresponding enzymes regulate the change of histones in two antagonist forms,acetylated or deacetylated.组蛋白乙酰转移酶(HAT)和组蛋白去乙酰化酶(HDAC)调节组蛋白乙酰化程度,HDAC在基因表达和染色体形成等方面起着重要的调节作用。
3.Histone acetyltransferases (HATs) andhistone deacetylases (HDACs) are emerging as important components of protein complexes that affect the dynamics of chromatin folding during gene transcription.组蛋白乙酰转移酶(histone acetyltransferases, HATs)和组蛋白去乙酰化酶(histone deacetylase, HDACs)可以通过调节组蛋白或转录因子的乙酰化状态来调节基因的活化或沉默。
4)Histone deacetylase组蛋白去乙酰化酶
1.Differentiation of PLZF-RARα-positive U937 leukemic cells induced by histone deacetylase inhibitor trichostatin A in combination with all-trans retinoic acid;组蛋白去乙酰化酶抑制剂曲古菌素A联合全反式维甲酸诱导PLZF-RARα阳性U937细胞分化
2.Synergistic cytotoxicity effect of histone deacetylase inhibitor combined with paclitaxel on lung cancer cell lines and its mechanism组蛋白去乙酰化酶抑制剂协同紫杉醇对人肺癌细胞株抑制作用及机制
3.Relationship Between Systemic Inflammation and Activity of Histone Deacetylase in Peripheral Blood Mononuclear Cells from COPD Patients慢性阻塞性肺病外周血单个核细胞中的组蛋白去乙酰化酶活性与全身炎症的关系
5)histone deacetyase 4组蛋白去乙酰化酶4
1.Expression ofhistone deacetyase 4 in human liver carcinoma cell line Bel-7402 and its significance;组蛋白去乙酰化酶4在人肝癌细胞Bel-7402中的表达及其意义
6)Sir2 histone deacetylaseSir2组蛋白去乙酰化酶
1.NAD~+ regulatesSir2 histone deacetylase activity, which is consumed in Sir2-catalyzed deacetylation rea.作为去乙酰化反应底物的NAD+正性调节Sir2组蛋白去乙酰化酶活性,NAD+代谢产物尼克酰胺对Sir2有负性调节作用,而有尼克酰胺参与的NAD+补救合成途径对于Sir2活性十分重要。
延伸阅读
组蛋白分子式：CAS号：性质：是指所有真核生物的核中，与DNA结合存在的碱性蛋白质的总称。分子量约10 000～20 000。通常含有H1，H2A，H2B，H3，H4等5种成分。除H1外，其他4种组蛋白均分别以二聚体(共八聚体)相结合，形成核小体核心。DNA便缠绕在核小体的核心上。而H1则与核小体间的DNA结合。因此，一般认为组蛋白作为结构支持体的作用比其基因调节作用更为重要。鸟类、两栖类等含有细胞核的红细胞中，含有一种叫H5的特殊组蛋白。此外，在停止增殖的细胞中，还含有一种叫H1°的组蛋白，H1°的结构与H5相类似。组蛋白可受到甲基化、乙酰化、磷酸化、聚ADP核糖酰化，以及与泛醌(ubiquinone)相结合等几种类型的修饰。组蛋白的修饰与染色质结构的变化及基因活性控制的相关性等等，是今后的重要研究课题。
