点击“蓝字”，轻松关注我们
1
摘要译文
背景：
尽管实施了加速康复外科（ERAS）和腹腔镜技术，但在结肠直肠手术后影响患者恢复和医疗保健资源的术后肠梗阻（POI）仍然很频繁。目前，没有可靠地预测或实现早期POI诊断的方式。挥发性有机化合物（VC）是人和微生物细胞代谢的产物，我们假设在POI中发生可检测的改变。
方法：这是一项前瞻性观察性研究，对在既定ERAS计划中接受腹腔镜结直肠切除术的患者进行了研究。标准化呼气末呼吸采样在手术当天早晨和手术前三个早晨进行。使用选择离子流管质谱法和GastroCH4ECK®分析VC浓度。记录可行性数据，包括肠道准备，术后口服摄入，POI和30天发病率。结果：在75名符合条件的患者中，58名（77％）同意参加。按协议呼吸采样成功完成94％。基线和术后VC水平大致相当，并且未通过肠道准备或术后口服摄入改变。POI在14名（29％）患者中出现。POI患者的术前氨浓度较高（830ppb vs. 510ppb，P = 0.027）。发生POI的患者在第2天乙酸增加（99ppb vs 171ppb，p = 0.021）。结论：在围手术期设置中，重复VC呼吸采样和分析是可行的。早晨手术氨浓度可能是POI的潜在预测因子。
2
原文摘要
长按二维码，
下 载 原 文！
Feasibility of perioperative volatile organic compound breath testing for the prediction of paralytic ileus following laparoscopic colorectal resection
Francis NK, Curtis NJ, Salib E, de Lacy Costello B, Lemm NM, Gould O, Crilly L, Allison J, Ratcliffe NColorectal Dis. Jul 25.doi: 10.1111/codi.14788.
AbstractBACKGROUND:Despite implementation of enhanced recovery after surgery (ERAS) and laparoscopic techniques postoperative ileus (POI) remains frequent after colorectal surgery impacting the patient, their recovery and healthcare resources. Presently there are no tests that reliably predict or enable early POI diagnosis. Volatile organic compounds (VC) are products of human and microbiota cellular metabolism and we hypothesised that a detectable alteration occurs in POI.
METHODS:This was a prospective observational study of patients undergoing laparoscopic colorectal resection within an established ERAS programme. Standardised end expiratory breath sampling was performed on the morning of surgery and the first three post-operative mornings. VC concentrations were analysed using Selected Ion Flow Tube Mass Spectrometry and GastroCH4 ECK®. Feasibility >
RESULTS:Of the 75 potentially eligible patients, 58 (77%) agreed to participate. Per-protocol breath sampling was successfully completed in 94%. There were no analytical failures. Baseline and post-operative VC levels were broadly comparable and were not altered by bowel preparation or post-operative oral intake. POI developed in 14 (29%) patients. Pre-operative ammonia concentration was higher in POI patients (830ppb vs. 510ppb, P=0.027). There was an Increase in acetic acid at day two in patients who developed POI (99ppb vs 171ppb, p=0.021).
CONCLUSION:Repeated VC breath sampling and analysis is feasible in the peri-operative setting. Morning of surgery ammonia concentration may be a potential predictor of POI.
音 频 收 听
Audio listening
每天进步一点点，
你的未来很精彩！
ERAS文献解读小组
微信号 : sh51
喜马拉雅音频号：ERAS最新文献解读
【胃肠外科】腹腔镜结直肠切除术后围手术期挥发性有机化合物呼气试验预测麻痹性肠梗阻的可行性
