Nothing can persuade her to change her mind it is made up.A. whenB. whileC. sinceD. once

问题补充：

Nothing can persuade her to change her mind it is made up.

A. when

B. while

C. since

D. once

答案：

A. when

B. while

C. since

(答案→)D. once

解析：本题的含义是他一旦做出决定，没有什么事情能够组织他改变想法，once可以表示一旦的意思，故本题选D。